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There is currently no cure for lupus but advances in medicines are improving treatment. The goal of treatment is to prevent flares, treat flares when they do occur, and reduce organ problems and other complications. Your doctors may prescribe medications to treat lupus directly as well as other conditions related to lupus; these include high cholesterol, high blood pressure, and infection.

Because lupus may affect different parts of your body in different ways, you may need to see several kinds of doctors. It is extremely important to have a singly physician coordinate your care and this is typically a Rheumatologist.

Another important part of living with lupus is that you see your doctor regularly, even when you’re feeling good. Regular visits to the doctor can help you manage your condition by looking for changes in symptoms, predicting and preventing flares, changing your treatment plan as needed, and detecting side effects of treatment. Specialists who may be part of your healthcare team include the following.

  • Rheumatologists (doctors who specialize in arthritis and other diseases that cause swelling in the joints)
  • Clinical immunologists (doctors who specialize in immune system disorders)
  • Nephrologists (doctors who specialize in kidney disorders)
  • Hematologists (doctors who specialize in blood disorders)
  • Dermatologists (doctors who specialize in skin diseases)
  • Neurologists (doctors who specialize in problems with the nervous system)
  • Cardiologists (doctors who specialize in heart and blood vessel problems)
  • Endocrinologists (doctors who specialize in gland and hormone problems)
  • Nurses
  • Occupational or physical therapist
  • Psychologists
  • Social workers

Medicines that your doctors may prescribe include aspirin or similar medicine to treat swollen joints and fever as well as creams for a rash. For severe cases of lupus, medical treatment may include immunosuppressive drugs, anti-malaria drugs, corticosteroids, and chemotherapy drugs.

For Women with Lupus

Two concerns particular to women with lupus are pregnancy and contraception.

  • Pregnancy: Even though pregnancy in women with lupus is considered high risk, most women with lupus can and do have healthy babies. They are encouraged to seek counseling before becoming pregnant, to see their doctors often, and to be prepared for a flare during pregnancy.
  • Contraception: According to recent studies, oral contraceptives, or birth control pills, are safe for women with lupus. Reliable birth control is necessary for women who do not wish to become pregnant and for those who are taking medicines that could be harmful to an unborn baby. Women should asked their doctor if any of the medicines that they’ve been prescribed carry such risks.

Living with Lupus

Because there is no cure for lupus, learning to live with disease and manage its symptoms will help you protect your health and maintain a good quality of life. A critical step in managing the symptoms of lupus is learning to recognize the warning signs of a flare. If you treat or stop these warning signs, you may be able to prevent a flare or make it less severe. Some people experience the following before a flare:

Preventing Flares

There are a variety of things that can trigger a flare—such as exposure to sunlight or an infection—but the most common recipe for disaster is a combination of stress and fatigue.

Most people need a lot of extra rest – people need to pace themselves and minimize stress. When possible, work part-time or work from home in a self-employed setting because this allows individuals to set their own hours and build in time for rest.

Steps you can take to prevent a flare include:

  • Learning the warning signs of a flare
  • Setting realistic goals and priorities so that you don’t over exert yourself
  • Limiting the time you spending in the sun
  • Eating a healthy diet
  • Finding ways to manage stress
  • Getting enough rest and quiet
  • Exercising moderately when possible (always consult your doctor before starting an exercise plan)

Having lupus can also be stressful and take an emotional toll. Many people manage stress by exercising and finding other ways to relax (yoga and meditation, for example). The support of family, friends, your doctors, community groups, and support groups can help you cope emotionally.

By staying actively involved in your own treatment, you’re more likely to have less pain, make fewer visits to the doctor, feel better about yourself, and remain more active. You’ll also learn to manage your energy, as it is likely limited, so that you can enjoy the events and activities that are most important to you.

Medications for Lupus

Anti-inflammatory and over-the-counter pain relievers can help to relieve symptoms from SLE by reducing inflammation and pain.

Aspirin - Pain-reducer with anti-inflammatory and anticoagulant (blood-thinning) properties.

Tylenol® (Acetaminophen) - Pain-reducer but not help with inflammation and cannot control lupus disease activity.

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) - Reduces inflammation and is especially useful for joint pain and stiffness. There are many different NSAID’s and people often do better with one particular NSAID than another. So, you may need to try several different ones to determine the best one for you. Learn more here….

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The cornerstone of treating any kind of lupus is cortisone-type drugs like prednisone. Lupus is pretty responsive to prednisone, but the problem is that it carries side effects. It’s best to start with a high dose and control the disease for a few weeks and then rapidly taper the dose if you can. It’s nice to get the dose to zero if you can, but that rarely happens.

Side effects of prednisone, aside from cosmetic changes like acne, face puffiness, and weight gain, prednisone can increase the risk of infection and diabetes, cause bruising and bone loss, and increase blood pressure. Prednisone can also exacerbate personality characteristics—so a cheerful person might become almost manic, whereas a more gloomy person might become extremely depressed. Steroids can produce a variety of side effects, including:

  • A round or moon-shaped face, weight gain or hair growth
  • Fluid retention and a redistribution of fat, leading to a swollen face and abdomen but thin arms and legs
  • Fragile skin that bruises easily.
  • Irritability, agitation, excitability
  • Insomnia
  • Depression.

Long-term steroid use can produce additional side effects

  • Increased risk of infections.
  • Avascular necrosis of bone. This occurs most often in the hip.
  • Osteoporosis or bone weakening which leads to bone fractures
  • Muscle weakness
  • Cataracts

Antimalarial Medications

Antimalarials improve lupus by decreasing auto-antibody production. This protects against the damaging effects of ultraviolet light from the sun and other sources and improving skin lesions. The two types of antimalarials most often prescribed today for lupus are hydroxychloroquine (Plaquenil®) and chloroquine (Aralen®). Unlike the rapid response seen with steroids, it may take months before antimalarial drugs improve your lupus symptoms.

Side effects from antimalarials are rare and usually mild. In high doses and over time, certain antimalarial drugs may damage the retina of the eye (retinal toxicity), causing vision problems. If low doses of antimalarials are used in the treatment of lupus, the risk of this complication is low. Long term plaquenil users on high doses will need to get check-ups for eye health regularly to prevent retinal toxicity from long-term use.

Immunosuppressives (Immune Modulators)

These include the chemotherapy agents Cytoxan® (cyclophosphamide) and Rheumatrex® (methotrexate) or another drug called Imuran® (azathioprine), which was designed to prevent the rejection of transplanted kidneys. Immunosuppressive medications are used to control inflammation and an overactive immune system. They are often used when prednisone fails to bring symptoms under control or when someone cannot tolerate high doses of prednisone. These drugs can cause severe side effects such as hair loss, sterility, and liver damage.

Voclosporin (Lupkynis™) Works by preventing an autoimmune response to reduce inflammation and damage to the kidneys known as lupus nephritis.

Cyclophosphamide (Cytoxan®) An immunosuppressant medication taken IV or orally that can improve kidney and lung disease.

Methotrexate (Rheumatrex™) An immunosuppressant medication shown to be very effective in treating skin lesions, arthritis and pleuritis in people with lupus.

Azathioprine (Imuran®) Blocks inflammation pathways in SLE and can help to lower steroid dosage and improve liver and kidney disease.

Monoclonal antibodies (mAbs)

A monoclonal antibody is a targeted drug that disrupts activation of B lymphocytes. Benlysta (belimumab) is a human monoclonal antibody was developed to disrupt activation of B lymphocytes by interfering with BLyS, a protein required for B cell activity. Benlysta is the first and only drug specifically developed for lupus. It is approved to treat lupus and lupus nephritis.


Blood clots can be a life-threatening complication of SLE. Anticoagulants thin the blood to prevent it from clotting too easily. Anticoagulant medications include;

  • low-dose aspirin
  • Heparin (Calciparine®, Liquaemin®)
  • warfarin (Coumadin®)-the dosage and administration of warfarin must be individualized for each person.

The Big Picture

For many people, living with lupus means learning to live with disease symptoms and the side effects of medication. It can be challenging to strike a happy balance, especially when the disease is a bit like a moving target.

  • Minimize stress.
  • Build in time for plenty of rest.
  • Maintain a healthy weight. This is challenging when taking steroids, but Dr. Hahn recommends at least not letting weight get into the obese range.
  • Maintain aerobic conditioning for even just a few minutes each day.
  • Eat a heart-healthy diet.
  • Avoid prolonged sun exposure and wear sunscreen, a hat, and ultraviolet-protective clothing.

SLE Resources & Support for Patients


  1. Systemic lupus erythematosus (SLE or lupus). Centers for Disease Control and Prevention website. Available at:
  2. National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at:
  3. Lupus: What Is Lupus? National Institute of Arthritis and Musculoskeletal and Skin Diseases website. Available at: