Skip to main content

by Dr. C. H. Weaver M.D. 12/2019

Fasinumab improve pain and function in patients with hip or knee arthritis who no looker derive relief from currently available analgesics according to study results published in Arthritis & Rheumatology.

About Fasinumab

Fasinumab is a a recombinant, fully - human anti-nerve-growth-factor antibody. It specifically blocks [nerve growth factor (NGF)] to treat pain and may obviate many of the side effects of currently used analgesic medications, such as opioids and nonsteroidal anti-inflammatory drugs (NSAIDs), which treat pain and inflammation differently.

In the current study 421 patients with moderate to severe knee or hip osteoarthritis and a history of inadequate response or intolerance to analgesics were treated with one of several different doses of fasinumab or a placebo every 4 weeks over a period of 16 weeks.

Study results demonstrated that patients receiving all 4 doses of fasinumab had significantly greater reductions in pain scores by the start of the secnd week of treatment and this was maintained throughout treatment.

Scroll to Continue



Treating Autism: How Omega-3 Fish Oil Helps

Reduced social contact and the performance of repetitive activities are two behavioral traits that are altered in the neurodevelopmental condition known as an autism spectrum disorder (ASD).


Collagen Peptide Daily Digestion Guidelines

The amino acids included in collagen are crucial for its healing, which helps to rebuild and strengthen the lining of our digestive tract.


Top 3 Private Home Nurse Caregiving Benefits

A specialized method of looking after and caring for ourselves or our loved ones is through private duty nursing services. Keep reading to learn the benefits.

A total of 25 arthropathies occurred in 7% of patients in fasinumab treated patients in a dose-dependent manner, with 2 occurring among patients in the 1-mg group compared with 12 in the 9-mg group.

Fasinumab may represent a new approach to managing joint pain however additional studies are required to determine the optimal dose. The researchers of the current study stated “The observation that the efficacy of lower doses was similar to that of higher doses but was associated with lower rates of arthropathy demands that future studies explore the benefit [vs] risk at these lower doses of fasinumab,”


Dakin P, DiMartino SJ, Gao H, et al. The efficacy, tolerability, and joint safety of fasinumab in osteoarthritis pain: a phase IIb/III double-blind, placebo-controlled, randomized clinical trial [published online June 17, 2019]. Arthritis Rheumatol. doi:10.1002/art.41012